[Impact of complicated myocardial injury on the clinical outcome of severe or critically ill COVID-19 patients].
Identifieur interne : 000063 ( an2020/Analysis ); précédent : 000062; suivant : 000064[Impact of complicated myocardial injury on the clinical outcome of severe or critically ill COVID-19 patients].
Auteurs : X W He [République populaire de Chine] ; J S Lai [République populaire de Chine] ; J. Cheng [République populaire de Chine] ; M W Wang [République populaire de Chine] ; Y J Liu [République populaire de Chine] ; Z C Xiao [République populaire de Chine] ; C. Xu [République populaire de Chine] ; S S Li [République populaire de Chine] ; H S Zeng [République populaire de Chine]Source :
- Zhonghua xin xue guan bing za zhi [ 0253-3758 ] ; 2020.
Abstract
Objective: To analyze the clinical characteristics of the severe or critically ill patients with novel coronavirus pneumonia (COVID-19), and evaluate the impact of complicated myocardial injury on the prognosis of these patients. Methods: A retrospective study was conducted in 54 patients who admitted to Tongji hospital from February 3, 2020 to February 24, 2020 and met the criteria of severe or critical conditions of COVID-19. The clinical characteristics and hospital mortality rate were analyzed and compared between the patients with or without myocardial injury, which was defined with 3 times higher serum cardiac troponin value. Results: The median age of the 54 patients was 68 (59.8, 74.3) years. Among all the patients, 24 (44.4%) patients were complicated with hypertension, 13 (24.1%) with diabetes, 8 (14.8%) with coronary heart disease, and 3 (5.6%) with previous cerebral infarction. During hospitalization, 24 (44.4%) of the patients were complicated with myocardial injury and 26 (48.1%) patients died in hospital. In-hospital mortality was significantly higher in patients with myocardial injury than in patients without myocardial injury (14 (60.9%) vs. 8 (25.8%), P=0.013). Moreover, the levels of C-reactive protein (153.6 (80.3, 240.7) ng/L vs. 49.8 (15.9, 101.9) ng/L) and N-terminal pro-B-type natriuretic peptide (852.0 (400.0, 2 315.3) ng/L vs. 197.0 (115.3, 631.0) ng/L) were significantly higher than patients without myocardial injury (all P<0.01). Conclusions: Prevalence of myocardial injury is high among severe or critically ill COVID-19 patients. Severe or critically ill COVID-19 patients with myocardial injury face a significantly higher risk of in-hospital mortality. The study suggests that it is important to monitor and manage the myocardial injury during hospitalization for severe or critically ill COVID-19 patients.
DOI: 10.3760/cma.j.cn112148-20200228-00137
PubMed: 32171190
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000509
- to stream PubMed, to step Curation: 000509
- to stream PubMed, to step Checkpoint: 000058
- to stream Ncbi, to step Merge: 001085
- to stream Ncbi, to step Curation: 001085
- to stream Ncbi, to step Checkpoint: 001085
- to stream Main, to step Merge: 000065
- to stream Main, to step Curation: 000063
- to stream Main, to step Exploration: 000063
- to stream an2020, to step Extraction: 000063
Links to Exploration step
pubmed:32171190Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Impact of complicated myocardial injury on the clinical outcome of severe or critically ill COVID-19 patients].</title><author><name sortKey="He, X W" sort="He, X W" uniqKey="He X" first="X W" last="He">X W He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Lai, J S" sort="Lai, J S" uniqKey="Lai J" first="J S" last="Lai">J S Lai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Cheng, J" sort="Cheng, J" uniqKey="Cheng J" first="J" last="Cheng">J. Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wang, M W" sort="Wang, M W" uniqKey="Wang M" first="M W" last="Wang">M W Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Liu, Y J" sort="Liu, Y J" uniqKey="Liu Y" first="Y J" last="Liu">Y J Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xiao, Z C" sort="Xiao, Z C" uniqKey="Xiao Z" first="Z C" last="Xiao">Z C Xiao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xu, C" sort="Xu, C" uniqKey="Xu C" first="C" last="Xu">C. Xu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Li, S S" sort="Li, S S" uniqKey="Li S" first="S S" last="Li">S S Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Emergency, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Emergency, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zeng, H S" sort="Zeng, H S" uniqKey="Zeng H" first="H S" last="Zeng">H S Zeng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32171190</idno><idno type="pmid">32171190</idno><idno type="doi">10.3760/cma.j.cn112148-20200228-00137</idno><idno type="wicri:Area/PubMed/Corpus">000509</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000509</idno><idno type="wicri:Area/PubMed/Curation">000509</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000509</idno><idno type="wicri:Area/PubMed/Checkpoint">000058</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000058</idno><idno type="wicri:Area/Ncbi/Merge">001085</idno><idno type="wicri:Area/Ncbi/Curation">001085</idno><idno type="wicri:Area/Ncbi/Checkpoint">001085</idno><idno type="wicri:doubleKey">0253-3758:2020:He X:impact:of:complicated</idno><idno type="wicri:Area/Main/Merge">000065</idno><idno type="wicri:Area/Main/Curation">000063</idno><idno type="wicri:Area/Main/Exploration">000063</idno><idno type="wicri:Area/an2020/Extraction">000063</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Impact of complicated myocardial injury on the clinical outcome of severe or critically ill COVID-19 patients].</title><author><name sortKey="He, X W" sort="He, X W" uniqKey="He X" first="X W" last="He">X W He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Lai, J S" sort="Lai, J S" uniqKey="Lai J" first="J S" last="Lai">J S Lai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Cheng, J" sort="Cheng, J" uniqKey="Cheng J" first="J" last="Cheng">J. Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wang, M W" sort="Wang, M W" uniqKey="Wang M" first="M W" last="Wang">M W Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Liu, Y J" sort="Liu, Y J" uniqKey="Liu Y" first="Y J" last="Liu">Y J Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xiao, Z C" sort="Xiao, Z C" uniqKey="Xiao Z" first="Z C" last="Xiao">Z C Xiao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xu, C" sort="Xu, C" uniqKey="Xu C" first="C" last="Xu">C. Xu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Li, S S" sort="Li, S S" uniqKey="Li S" first="S S" last="Li">S S Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Emergency, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Emergency, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zeng, H S" sort="Zeng, H S" uniqKey="Zeng H" first="H S" last="Zeng">H S Zeng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">Zhonghua xin xue guan bing za zhi</title><idno type="ISSN">0253-3758</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><b>Objective:</b> To analyze the clinical characteristics of the severe or critically ill patients with novel coronavirus pneumonia (COVID-19), and evaluate the impact of complicated myocardial injury on the prognosis of these patients. <b>Methods:</b> A retrospective study was conducted in 54 patients who admitted to Tongji hospital from February 3, 2020 to February 24, 2020 and met the criteria of severe or critical conditions of COVID-19. The clinical characteristics and hospital mortality rate were analyzed and compared between the patients with or without myocardial injury, which was defined with 3 times higher serum cardiac troponin value. <b>Results:</b> The median age of the 54 patients was 68 (59.8, 74.3) years. Among all the patients, 24 (44.4%) patients were complicated with hypertension, 13 (24.1%) with diabetes, 8 (14.8%) with coronary heart disease, and 3 (5.6%) with previous cerebral infarction. During hospitalization, 24 (44.4%) of the patients were complicated with myocardial injury and 26 (48.1%) patients died in hospital. In-hospital mortality was significantly higher in patients with myocardial injury than in patients without myocardial injury (14 (60.9%) vs. 8 (25.8%), <i>P</i>=0.013). Moreover, the levels of C-reactive protein (153.6 (80.3, 240.7) ng/L vs. 49.8 (15.9, 101.9) ng/L) and N-terminal pro-B-type natriuretic peptide (852.0 (400.0, 2 315.3) ng/L vs. 197.0 (115.3, 631.0) ng/L) were significantly higher than patients without myocardial injury (all <i>P</i><0.01). <b>Conclusions:</b> Prevalence of myocardial injury is high among severe or critically ill COVID-19 patients. Severe or critically ill COVID-19 patients with myocardial injury face a significantly higher risk of in-hospital mortality. The study suggests that it is important to monitor and manage the myocardial injury during hospitalization for severe or critically ill COVID-19 patients.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="He, X W" sort="He, X W" uniqKey="He X" first="X W" last="He">X W He</name></region><name sortKey="Cheng, J" sort="Cheng, J" uniqKey="Cheng J" first="J" last="Cheng">J. Cheng</name><name sortKey="Lai, J S" sort="Lai, J S" uniqKey="Lai J" first="J S" last="Lai">J S Lai</name><name sortKey="Li, S S" sort="Li, S S" uniqKey="Li S" first="S S" last="Li">S S Li</name><name sortKey="Liu, Y J" sort="Liu, Y J" uniqKey="Liu Y" first="Y J" last="Liu">Y J Liu</name><name sortKey="Wang, M W" sort="Wang, M W" uniqKey="Wang M" first="M W" last="Wang">M W Wang</name><name sortKey="Xiao, Z C" sort="Xiao, Z C" uniqKey="Xiao Z" first="Z C" last="Xiao">Z C Xiao</name><name sortKey="Xu, C" sort="Xu, C" uniqKey="Xu C" first="C" last="Xu">C. Xu</name><name sortKey="Zeng, H S" sort="Zeng, H S" uniqKey="Zeng H" first="H S" last="Zeng">H S Zeng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/an2020/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000063 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd -nk 000063 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= an2020
|étape= Analysis
|type= RBID
|clé= pubmed:32171190
|texte= [Impact of complicated myocardial injury on the clinical outcome of severe or critically ill COVID-19 patients].
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/an2020/Analysis/RBID.i -Sk "pubmed:32171190" \
| HfdSelect -Kh $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |